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Monday, November 12, 2012

The Process of Tissue Repair

They have a a good deal longer lifespan than PMNs. Macrophages also release a derive of chemical factors which attract other cells to the site, decontaminate and debride the trauma, and release emergence factors which promote granulation wander formation to close the wound. each(prenominal) these transmitters are known as cytokines. T-lymphocytes appear around the 5th day.

The proliferative phase follows, and is characterized by the formation of granulation tissue in the wound (Wound). Granulation tissue consists of cellular divisions and new capillaries insert in a loose extracellular intercellular substance of collagen, fibronectin, and hyaluronic back breaker. Fibroblasts in the granulation tissue are the primary synthetic element in the repair tissue. Capillary buds sprout from blood vessels attached to the wound and the capillaries grow into the wound space. Re-epithelialization of the wound begins within a couple of hours of injury, with the epithelium growing in from the sides of the wound, or from islands of rest epithelial tissue. From seven days to one year is the ageing phase for wound mend (Wound). First an extracellular matrix is laid down, then reorganization begins. The extracellular matrix is comfortable in fibronectin, forming a provisional meshwork which acts as a substratum for migration and ingrowth of cells, and is a template for collagen deposition by fibroblasts. Hyaluronic acid and proteoglycans are also


Ross, M. H., Romrell, L. J., & Kaye, G. I. Histology: A text and Atlas. Baltimore, MD: Williams & Wilkins. 1995.

2. Name four important functions of epithelial tissue and provide at least one example of a tissue that exemplifies each function.
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Protection/barrier: A trice type of epithelium is stratified squamous epithelium, which is found in the carapace (Ross, Romrell and Kaye 59). It serves as a barrier, protecting the body from outside agents which may be harmful. This type of epithelium also lines the oral nether region and the esophagus, and the vagina, where it serves similar protective functions.

Factors influencing wound healing include the size of the wound, depth of the wound, whether there is significant tissue loss, how much handicap there is to blood vessels in the area, nerve damage in the wound area, nutritional status of the patient (certain vitamin deficiencies delay wound healing), metabolic disorders such as diabetes which delay wound healing, and how liberal it is to stabilize the wound site, since any movements which pull the wound capable will delay healing.

present. The collagen fibers become crosslinked, giving strength to the healing tissues.


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